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Quinolones and repolarization

Quinolones appear to prolong repolarization [3] in a dose-dependent fashion. Sporadic cases of long-QT syndrome are reported[1,2], all of them in women, with torsade of points when associated with other drugs such as Amiodarone.

1. Letsas KP, Sideris A, Kounas SP, Efremidis M, Korantzopoulos P, Kardaras F. Drug-induced QT interval prolongation after ciprofloxacin administration in a patient receiving olanzapine. Int J Cardiol. 2005 May 31.

2. Prabhakar M, Krahn AD. Ciprofloxacin-induced acquired long QT syndrome. Heart Rhythm. 2004 Nov;1(5):624-6.

3. Patmore L, Fraser S, Mair D, Templeton A. Effects of sparfloxacin, grepafloxacin, moxifloxacin, and ciprofloxacin on cardiac action potential duration. Eur J Pharmacol. 2000 Oct 20;406(3):449-52.

[Copyright (c) 2004 A.D. Corlan]